INSM1

Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.^[5][6][7]

INSM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LV2, 3ZMS
Identifiers
Aliases	INSM1, IA-1, IA1, INSM transcriptional repressor 1
External IDs	OMIM: 600010; MGI: 1859980; HomoloGene: 31080; GeneCards: INSM1; OMA:INSM1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.23 Start 20,368,104 bp[1] End 20,370,949 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G1 Start 146,063,841 bp[2] End 146,066,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell ganglionic eminence ventricular zone pituitary gland anterior pituitary cerebellar vermis cerebellar hemisphere right hemisphere of cerebellum paraflocculus of cerebellum putamen Top expressed in medial ganglionic eminence Rostral migratory stream pineal gland ventricular zone islet of Langerhans fossa lumbar spinal ganglion trigeminal ganglion olfactory system olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity histone deacetylase binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding chromatin DNA binding cyclin binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription repressor complex nucleoplasm nucleus Biological process sympathetic ganglion development negative regulation of protein phosphorylation noradrenergic neuron development cell differentiation regulation of transcription, DNA-templated norepinephrine biosynthetic process positive regulation of cell migration pancreatic A cell differentiation negative regulation of transcription by RNA polymerase II nervous system development transcription, DNA-templated multicellular organism development positive regulation of neural precursor cell proliferation adrenal chromaffin cell differentiation endocrine system development positive regulation of cell differentiation positive regulation of cell population proliferation regulation of gene expression cell cycle type B pancreatic cell development regulation of protein-containing complex assembly type B pancreatic cell differentiation endocrine pancreas development negative regulation of cell population proliferation transdifferentiation regulation of cell cycle process neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3642 53626 Ensembl ENSG00000173404 ENSMUSG00000068154 UniProt Q01101 Q63ZV0 RefSeq (mRNA) NM_002196 NM_016889 RefSeq (protein) NP_002187 NP_058585 Location (UCSC) Chr 20: 20.37 – 20.37 Mb Chr 2: 146.06 – 146.07 Mb PubMed search [3] [4]
Wikidata
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Function

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.^{[7] [8]}

Interactions

INSM1 has been shown to interact with SORBS1.^[9]