INSRR

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.^[5][6][7]

INSRR
Identifiers
Aliases	INSRR, IRR, insulin receptor related receptor
External IDs	OMIM: 147671; MGI: 1346037; HomoloGene: 56539; GeneCards: INSRR; OMA:INSRR - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 156,840,063 bp[1] End 156,859,117 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.7 cM Start 87,704,258 bp[2] End 87,723,408 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of stomach human kidney body of uterus right testis apex of heart myometrium canal of the cervix fundus left testis abdominal wall Top expressed in islet of Langerhans right kidney cingulate gyrus embryo internal carotid artery external carotid artery central gray substance of midbrain glossopharyngeal ganglion nucleus of stria terminalis human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane receptor protein tyrosine kinase activity phosphatidylinositol 3-kinase binding insulin receptor substrate binding nucleotide binding protein kinase activity protein tyrosine kinase activity transferase activity ATP binding kinase activity receptor tyrosine kinase transmembrane signaling receptor activity insulin-activated receptor activity Cellular component receptor complex integral component of membrane integral component of plasma membrane membrane cytoplasm insulin receptor complex axon Biological process actin cytoskeleton reorganization protein autophosphorylation protein phosphorylation cellular response to alkaline pH male sex determination phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway peptidyl-tyrosine phosphorylation insulin receptor signaling pathway negative regulation of signal transduction cell differentiation glucose homeostasis negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade anatomical structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3645 23920 Ensembl ENSG00000027644 ENSMUSG00000005640 UniProt P14616 Q9WTL4 RefSeq (mRNA) NM_014215 NM_011832 RefSeq (protein) NP_055030 NP_035962 Location (UCSC) Chr 1: 156.84 – 156.86 Mb Chr 3: 87.7 – 87.72 Mb PubMed search [3] [4]
Wikidata
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