INTS1

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. ^[5]

INTS1
Identifiers
Aliases	INTS1, INT1, NET28, integrator complex subunit 1, NDCAGF
External IDs	OMIM: 611345; MGI: 1915760; HomoloGene: 53111; GeneCards: INTS1; OMA:INTS1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 1,470,277 bp[1] End 1,504,389 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 139,737,037 bp[2] End 139,761,429 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis apex of heart right frontal lobe right hemisphere of cerebellum mucosa of transverse colon anterior pituitary right lobe of thyroid gland left lobe of thyroid gland right uterine tube Top expressed in tail of embryo genital tubercle spermatocyte neural layer of retina primary visual cortex superior frontal gyrus ventricular zone yolk sac muscle of thigh spermatid More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 26173 68510 Ensembl ENSG00000164880 ENSMUSG00000029547 UniProt Q8N201 Q6P4S8 RefSeq (mRNA) NM_001080453 NM_026748 RefSeq (protein) NP_001073922 NP_081024 Location (UCSC) Chr 7: 1.47 – 1.5 Mb Chr 5: 139.74 – 139.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).