INTS12

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene.^[4]

INTS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEV
Identifiers
Aliases	INTS12, INT12, PHF22, SBBI22, integrator complex subunit 12
External IDs	OMIM: 611355; MGI: 1919043; HomoloGene: 32474; GeneCards: INTS12; OMA:INTS12 - orthologs
Gene location (Mouse) Chr. Chromosome 3 (mouse)[1] Band 3|3 G3 Start 132,797,601 bp[1] End 132,816,749 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right ventricle islet of Langerhans gastrocnemius muscle jejunal mucosa triceps brachii muscle ganglionic eminence biceps brachii Achilles tendon Top expressed in secondary oocyte genital tubercle zygote primary oocyte tail of embryo granulocyte otic placode medial ganglionic eminence epiblast maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding Cellular component integrator complex nucleoplasm nucleus Biological process snRNA processing snRNA transcription by RNA polymerase II snRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57117 71793 Ensembl n/a ENSMUSG00000028016 UniProt Q96CB8 Q9D168 RefSeq (mRNA) NM_001142471 NM_020395 NM_027927 RefSeq (protein) NP_001135943 NP_065128 NP_001135943.1 NP_065128.2 NP_082203 Location (UCSC) n/a Chr 3: 132.8 – 132.82 Mb PubMed search [2] [3]
Wikidata
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INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2)^[4][5]