IPO8

Importin 8 is a protein that in humans is encoded by the IPO8 gene.^[5]

IPO8
Identifiers
Aliases	IPO8, RANBP8, importin 8, VISS
External IDs	OMIM: 605600; MGI: 2444611; HomoloGene: 48430; GeneCards: IPO8; OMA:IPO8 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.21 Start 30,628,988 bp[1] End 30,695,869 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G3 Start 148,770,683 bp[2] End 148,831,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tendon of biceps brachii internal globus pallidus skin of hip mucosa of sigmoid colon Achilles tendon buccal mucosa cell superficial temporal artery seminal vesicula jejunal mucosa Top expressed in secondary oocyte zygote primary oocyte cumulus cell epithelium of lens medial vestibular nucleus central gray substance of midbrain pituitary gland superior cervical ganglion left lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus nucleoplasm nuclear envelope cytosol Biological process protein transport intracellular protein transport signal transduction regulation of gene silencing by miRNA protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10526 320727 Ensembl ENSG00000133704 ENSMUSG00000040029 UniProt O15397 Q7TMY7 RefSeq (mRNA) NM_001190995 NM_006390 NM_001081113 RefSeq (protein) NP_001177924 NP_006381 NP_001074582 Location (UCSC) Chr 12: 30.63 – 30.7 Mb Chr 6: 148.77 – 148.83 Mb PubMed search [3] [4]
Wikidata
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Function

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].