IRAK2

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.^[5][6]

IRAK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MOP
Identifiers
Aliases	IRAK2, IRAK-2, interleukin 1 receptor associated kinase 2
External IDs	OMIM: 603304; MGI: 2429603; HomoloGene: 1207; GeneCards: IRAK2; OMA:IRAK2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,164,919 bp[1] End 10,243,745 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.82 cM Start 113,615,428 bp[2] End 113,671,987 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue pancreatic epithelial cell secondary oocyte pancreatic ductal cell palpebral conjunctiva gastrocnemius muscle tibialis anterior muscle amniotic fluid endothelial cell islet of Langerhans Top expressed in granulocyte jejunum urinary bladder white adipose tissue spleen left lung colon proximal tubule duodenum ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity protein homodimerization activity protein serine/threonine kinase activity protein binding protein heterodimerization activity ATP binding Cellular component cytoplasm cytosol plasma membrane endosome membrane nucleus Biological process response to interleukin-1 negative regulation of DNA-binding transcription factor activity toll-like receptor signaling pathway protein phosphorylation JNK cascade positive regulation of NF-kappaB transcription factor activity toll-like receptor 9 signaling pathway negative regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing signaling pathway lipopolysaccharide-mediated signaling pathway signal transduction regulation of cytokine-mediated signaling pathway I-kappaB kinase/NF-kappaB signaling inflammatory response MyD88-dependent toll-like receptor signaling pathway intracellular signal transduction interleukin-1-mediated signaling pathway cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3656 108960 Ensembl ENSG00000134070 ENSMUSG00000060477 UniProt O43187 Q8CFA1 RefSeq (mRNA) NM_001570 NM_001113553 NM_172161 RefSeq (protein) NP_001561 NP_001107025 NP_751893 Location (UCSC) Chr 3: 10.16 – 10.24 Mb Chr 6: 113.62 – 113.67 Mb PubMed search [3] [4]
Wikidata
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Function

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.^[6]

Interactions

IRAK2 has been shown to interact with TRAF6^[5][7] and Myd88.^[5][7][8]