IRX2

Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.^[5][6]

IRX2
Identifiers
Aliases	IRX2, IRXA2, iroquois homeobox 2
External IDs	OMIM: 606198; MGI: 1197526; HomoloGene: 56490; GeneCards: IRX2; OMA:IRX2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.33 Start 2,745,845 bp[1] End 2,751,677 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 C1|13 39.23 cM Start 72,776,939 bp[2] End 72,782,317 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm lower lobe of lung lactiferous duct parotid gland skin of thigh Pons renal medulla bronchial epithelial cell nipple buccal mucosa cell Top expressed in pretectal area otic placode lip otic vesicle saccule lacrimal gland epidermis zone of skin skin of abdomen skin of back More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process specification of loop of Henle identity metanephros development regulation of transcription, DNA-templated proximal/distal pattern formation involved in metanephric nephron development negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 153572 16372 Ensembl ENSG00000170561 ENSMUSG00000001504 UniProt Q9BZI1 P81066 RefSeq (mRNA) NM_001134222 NM_033267 NM_010574 RefSeq (protein) NP_001127694 NP_150366 NP_034704 Location (UCSC) Chr 5: 2.75 – 2.75 Mb Chr 13: 72.78 – 72.78 Mb PubMed search [3] [4]
Wikidata
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Function

IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.^[5]

Cancer

IRX2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. ^[7] For this reason, IRX2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. ^[7]