IRX4

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.^[5][6]

IRX4
Identifiers
Aliases	IRX4, IRXA3, iroquois homeobox 4
External IDs	OMIM: 606199; MGI: 1355275; HomoloGene: 9485; GeneCards: IRX4; OMA:IRX4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.33 Start 1,877,413 bp[1] End 1,887,236 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C1 Start 73,408,598 bp[2] End 73,417,727 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen apex of heart skin of leg hair follicle gonad left ventricle minor salivary glands vagina right ventricle epithelium of lactiferous gland Top expressed in lip ventricle of the heart atrioventricular canal endocardial cushion myocardium of ventricle cardiac muscles right ventricle atrioventricular valve primordial ventricle upper lip More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process heart development regulation of transcription, DNA-templated establishment of animal organ orientation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50805 50916 Ensembl ENSG00000113430 ENSMUSG00000021604 UniProt P78413 Q9QY61 RefSeq (mRNA) NM_016358 NM_001278632 NM_001278633 NM_001278634 NM_001278635 NM_018885 RefSeq (protein) NP_001265561 NP_001265562 NP_001265563 NP_001265564 NP_057442 NP_061373 Location (UCSC) Chr 5: 1.88 – 1.89 Mb Chr 13: 73.41 – 73.42 Mb PubMed search [3] [4]
Wikidata
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Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.^[5]