IRX6

Iroquois-class homeodomain protein IRX-6, also known as Iroquois homeobox protein 6, is a protein that in humans is encoded by the IRX6 gene.^[5][6]

IRX6
Identifiers
Aliases	IRX6, IRX-3, IRX7, IRXB3, iroquois homeobox 6
External IDs	OMIM: 606196; MGI: 1927642; HomoloGene: 41481; GeneCards: IRX6; OMA:IRX6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q12.2 Start 55,324,203 bp[1] End 55,330,756 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C5|8 44.99 cM Start 93,400,916 bp[2] End 93,407,584 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart skin of abdomen muscle of thigh skin of leg subcutaneous adipose tissue left ventricle lactiferous gland gastrocnemius muscle skeletal muscle tissue salivary gland Top expressed in endocardium of ventricle urethra male urethra endocardium of atrium embryo neural layer of retina greater petrosal nerve extraocular muscle genital tubercle vestibular membrane of cochlear duct More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79190 64379 Ensembl ENSG00000159387 ENSMUSG00000031738 UniProt P78412 Q9ER75 RefSeq (mRNA) NM_024335 NM_001301137 NM_022428 RefSeq (protein) NP_077311 NP_001288066 NP_071873 Location (UCSC) Chr 16: 55.32 – 55.33 Mb Chr 8: 93.4 – 93.41 Mb PubMed search [3] [4]
Wikidata
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Function

IRX6 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.^[5]