ISCA1

Iron-sulfur cluster assembly 1 homolog, mitochondrial is an evolutionarily highly conserved protein for the biogenesis of iron-sulfur cluster across species.^[5] In humans it is encoded by the ISCA1 gene.^[6][7]

ISCA1
Identifiers
Aliases	ISCA1, HBLD2, ISA1, hIscA, iron-sulfur cluster assembly 1, MMDS5
External IDs	OMIM: 611006; MGI: 1916296; HomoloGene: 87862; GeneCards: ISCA1; OMA:ISCA1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.33 Start 86,264,546 bp[1] End 86,283,102 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B2 Start 59,903,223 bp[2] End 59,917,624 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell biceps brachii Skeletal muscle tissue of biceps brachii right ventricle trabecular bone kidney tubule Epithelium of choroid plexus pons myocardium Brodmann area 23 Top expressed in bone marrow brown adipose tissue tibialis anterior muscle soleus muscle quadriceps femoris muscle masseter muscle extraocular muscle myocardium of ventricle muscle of thigh cardiac muscles More reference expression data BioGPS n/a
Gene ontology Molecular function iron-sulfur cluster binding ferrous iron binding structural molecule activity metal ion binding 2 iron, 2 sulfur cluster binding Cellular component mitochondrion mitochondrial matrix Biological process iron-sulfur cluster assembly protein maturation by iron-sulfur cluster transfer small molecule metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81689 69046 Ensembl ENSG00000135070 ENSMUSG00000044792 UniProt Q9BUE6 Q9D924 RefSeq (mRNA) NM_030940 NM_026921 RefSeq (protein) NP_112202 NP_081197 Location (UCSC) Chr 9: 86.26 – 86.28 Mb Chr 13: 59.9 – 59.92 Mb PubMed search [3] [4]
Wikidata
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