ISG20

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.^[5][6][7]

ISG20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WLJ
Identifiers
Aliases	ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20
External IDs	OMIM: 604533; MGI: 1928895; HomoloGene: 31081; GeneCards: ISG20; OMA:ISG20 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 88,635,670 bp[1] End 88,656,483 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D2 Start 78,563,172 bp[2] End 78,570,144 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen blood granulocyte lymph node cartilage tissue appendix duodenum jejunal mucosa epithelium of nasopharynx right lung Top expressed in tibiofemoral joint blood spermatid islet of Langerhans spleen decidua right lung lobe gastrula thymus fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity single-stranded DNA 3'-5' exodeoxyribonuclease activity exoribonuclease II activity metal ion binding U3 snoRNA binding U2 snRNA binding RNA binding nucleic acid binding U1 snRNA binding nuclease activity exonuclease activity hydrolase activity Cellular component cytoplasm Cajal body PML body nucleoplasm nucleolus nucleus Biological process immune system process response to virus RNA catabolic process negative regulation of viral genome replication DNA catabolic process, exonucleolytic defense response to virus type I interferon signaling pathway rRNA processing innate immune response cell population proliferation RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3669 57444 Ensembl ENSG00000172183 ENSMUSG00000039236 UniProt Q96AZ6 Q9JL16 RefSeq (mRNA) NM_001303233 NM_001303234 NM_001303235 NM_001303236 NM_001303237 NM_002201 NM_001113527 NM_001291220 NM_001291221 NM_020583 RefSeq (protein) NP_001290162 NP_001290163 NP_001290164 NP_001290165 NP_001290166 NP_002192 NP_001106999 NP_001278149 NP_001278150 NP_065608 Location (UCSC) Chr 15: 88.64 – 88.66 Mb Chr 7: 78.56 – 78.57 Mb PubMed search [3] [4]
Wikidata
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