Integrin alpha 2b

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.^[5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[6]

ITGA2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DPK, 1DPQ, 1KUP, 1KUZ, 1M8O, 1S4W, 1TYE, 2K1A, 2K9J, 2KNC, 2MTP, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4Z7O, 4Z7Q, 5HDB, 4Z7N
Identifiers
Aliases	ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
External IDs	OMIM: 607759; MGI: 96601; HomoloGene: 37304; GeneCards: ITGA2B; OMA:ITGA2B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,372,180 bp[1] End 44,389,649 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 66.29 cM Start 102,344,123 bp[2] End 102,360,948 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood trabecular bone granulocyte pancreatic ductal cell gonad testicle right hemisphere of cerebellum bone marrow cells sperm Top expressed in blood tibiofemoral joint embryo yolk sac spleen lip body of femur right kidney gastrula granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding fibrinogen binding extracellular matrix binding identical protein binding metal ion binding Cellular component focal adhesion integrin complex integral component of plasma membrane platelet alpha granule membrane integral component of membrane membrane external side of plasma membrane extracellular exosome plasma membrane blood microparticle cell surface Biological process extracellular matrix organization cell-matrix adhesion positive regulation of leukocyte migration platelet aggregation platelet degranulation cell adhesion integrin-mediated signaling pathway regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3674 16399 Ensembl ENSG00000005961 ENSMUSG00000034664 UniProt P08514 Q9QUM0 RefSeq (mRNA) NM_000419 NM_010575 RefSeq (protein) NP_000410 NP_034705 Location (UCSC) Chr 17: 44.37 – 44.39 Mb Chr 11: 102.34 – 102.36 Mb PubMed search [3] [4]
Wikidata
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Interactions

ITGA2B has been shown to interact with AUP1^[7] and CLNS1A.^[8]

See also

• Cluster of differentiation
• Glycoprotein IIb/IIIa