AUP1

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.^[5][6][7]

AUP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EKF
Identifiers
Aliases	AUP1, ancient ubiquitous protein 1, lipid droplet regulating VLDL assembly factor, AUP1 lipid droplet regulating VLDL assembly factor
External IDs	OMIM: 602434; MGI: 107789; HomoloGene: 7239; GeneCards: AUP1; OMA:AUP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,526,645 bp[1] End 74,529,760 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3|6 35.94 cM Start 83,031,502 bp[2] End 83,034,789 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte body of pancreas mucosa of transverse colon body of stomach left lobe of thyroid gland right lobe of thyroid gland tendon of biceps brachii spleen right lobe of liver minor salivary glands Top expressed in right kidney granulocyte muscle of thigh proximal tubule choroid plexus of fourth ventricle yolk sac neural layer of retina lip superior frontal gyrus primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin binding ubiquitin-protein transferase activator activity protein binding Cellular component extracellular exosome endoplasmic reticulum membrane membrane integral component of endoplasmic reticulum membrane Hrd1p ubiquitin ligase ERAD-L complex integral component of membrane endoplasmic reticulum Biological process retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 550 11993 Ensembl ENSG00000115307 ENSMUSG00000068328 UniProt Q9Y679 P70295 RefSeq (mRNA) NM_181575 NM_001025446 NM_001301649 NM_007517 RefSeq (protein) NP_853553 NP_001288578 NP_031543 Location (UCSC) Chr 2: 74.53 – 74.53 Mb Chr 6: 83.03 – 83.03 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.^[7]

Interactions

AUP1 has been shown to interact with ITGA2B.^[6]