ITM2A

Integral membrane protein 2A is a protein that in humans is encoded by the ITM2A gene.^[5][6][7][8]

ITM2A
Identifiers
Aliases	ITM2A, BRICD2A, E25A, integral membrane protein 2A
External IDs	OMIM: 300222; MGI: 107706; HomoloGene: 31269; GeneCards: ITM2A; OMA:ITM2A - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 79,360,384 bp[1] End 79,367,667 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 106,440,705 bp[2] End 106,446,982 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus cartilage tissue vena cava subthalamic nucleus internal globus pallidus lateral nuclear group of thalamus inferior ganglion of vagus nerve lactiferous duct ventral tegmental area Epithelium of choroid plexus Top expressed in calvaria efferent ductule condyle fossa human fetus dermis vas deferens umbilical cord endocardial cushion Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding amyloid-beta binding Cellular component membrane integral component of membrane Golgi apparatus plasma membrane extracellular exosome Biological process plasma cell differentiation immunoglobulin production nervous system development negative regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9452 16431 Ensembl ENSG00000078596 ENSMUSG00000031239 UniProt O43736 Q61500 RefSeq (mRNA) NM_004867 NM_001171581 NM_008409 RefSeq (protein) NP_001165052 NP_004858 NP_032435 Location (UCSC) Chr X: 79.36 – 79.37 Mb Chr X: 106.44 – 106.45 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is involved in osteo- and chondrogenic cellular differentiation (the cells which are responsible for the development of bone and cartilage respectively).^[6]

ITM2A is also involved in activation of T-cells in the immune system^[9] and in myocyte differentiation.^[10]