ITPK1

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.^[5][6][7]

ITPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q7D, 2ODT, 2QB5
Identifiers
Aliases	ITPK1, ITRPK1, inositol-tetrakisphosphate 1-kinase
External IDs	OMIM: 601838; MGI: 2446159; HomoloGene: 8588; GeneCards: ITPK1; OMA:ITPK1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 92,936,914 bp[1] End 93,116,320 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 102,534,841 bp[2] End 102,671,189 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right frontal lobe anterior cingulate cortex prefrontal cortex amygdala nucleus accumbens sural nerve Brodmann area 9 right coronary artery caudate nucleus Top expressed in gastrula choroid plexus of fourth ventricle decidua crypt of lieberkuhn of small intestine intestinal villus ileum duodenum jejunum epithelium of small intestine CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding isomerase activity metal ion binding kinase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity catalytic activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity inositol-3,4,6-trisphosphate 1-kinase activity ATP binding hydrolase activity magnesium ion binding inositol-1,3,4-trisphosphate 6-kinase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity inositol-1,3,4-trisphosphate 5-kinase activity inositol tetrakisphosphate 1-kinase activity inositol tetrakisphosphate 6-kinase activity Cellular component cytosol intracellular anatomical structure apical plasma membrane cytoplasm Biological process phosphorylation blood coagulation inositol phosphate metabolic process inositol trisphosphate metabolic process neural tube development signal transduction dephosphorylation necroptosis inositol phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3705 217837 Ensembl ENSG00000100605 ENSG00000274958 ENSMUSG00000057963 UniProt Q13572 Q8BYN3 RefSeq (mRNA) NM_014216 NM_001142593 NM_001142594 NM_001363707 NM_172584 RefSeq (protein) NP_001136065 NP_001136066 NP_055031 NP_001350636 NP_766172 Location (UCSC) Chr 14: 92.94 – 93.12 Mb Chr 12: 102.53 – 102.67 Mb PubMed search [3] [4]
Wikidata
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It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.^[8][9]