ITPR2

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene.^[5] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.^[6]

ITPR2
Identifiers
Aliases	ITPR2, CFAP48, IP3R2, ANHD, INSP3R2, inositol 1,4,5-trisphosphate receptor type 2
External IDs	OMIM: 600144; MGI: 99418; HomoloGene: 37593; GeneCards: ITPR2; OMA:ITPR2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.23 Start 26,335,352 bp[1] End 26,833,194 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G3|6 77.7 cM Start 146,009,797 bp[2] End 146,403,721 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon germinal epithelium skin of thigh epithelium of colon skin of hip sural nerve liver oral cavity bone marrow cells lactiferous duct Top expressed in Ileal epithelium zygote oocyte primary oocyte secondary oocyte corneal stroma thymus blood ankle joint brown adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity calcium-release channel activity calcium ion transmembrane transporter activity ion channel activity calcium ion binding phosphatidylinositol binding inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity scaffold protein binding inositol 1,4,5 trisphosphate binding Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane membrane receptor complex plasma membrane sarcoplasmic reticulum cell cortex platelet dense tubular network membrane sarcoplasmic reticulum membrane nucleus endoplasmic reticulum cytoplasmic vesicle membrane secretory granule membrane Biological process regulation of cardiac conduction response to hypoxia cellular response to ethanol regulation of insulin secretion ion transport platelet activation calcium ion transmembrane transport transmembrane transport inositol phosphate-mediated signaling cellular response to cAMP signal transduction calcium ion transport release of sequestered calcium ion into cytosol transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3709 16439 Ensembl ENSG00000123104 ENSMUSG00000030287 UniProt Q14571 Q9Z329 RefSeq (mRNA) NM_002223 NM_010586 NM_019923 RefSeq (protein) NP_002214 NP_034716 NP_064307 Location (UCSC) Chr 12: 26.34 – 26.83 Mb Chr 6: 146.01 – 146.4 Mb PubMed search [3] [4]
Wikidata
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See also

• Inositol trisphosphate receptor