ITPR3

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.^[5] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.^[6]

ITPR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JRR
Identifiers
Aliases	ITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
External IDs	OMIM: 147267; MGI: 96624; HomoloGene: 1675; GeneCards: ITPR3; OMA:ITPR3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 33,620,365 bp[1] End 33,696,574 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 13.68 cM Start 27,276,278 bp[2] End 27,341,197 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue pylorus skin of arm trigeminal ganglion sural nerve skin of thigh olfactory bulb left lobe of thyroid gland spinal ganglia right lobe of thyroid gland Top expressed in molar pyloric antrum epithelium of stomach skin of external ear mucous cell of stomach lip epithelium of small intestine sciatic nerve rib left colon More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ion channel activity protein binding inositol 1,3,4,5 tetrakisphosphate binding calcium-release channel activity inositol hexakisphosphate binding inositol 1,4,5 trisphosphate binding calcium ion binding phosphatidylinositol binding Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane membrane receptor complex plasma membrane apical part of cell integral component of plasma membrane nucleoplasm nucleolus platelet dense tubular network membrane endoplasmic reticulum brush border nucleus nuclear outer membrane myelin sheath soma sarcoplasmic reticulum cytoplasmic vesicle membrane secretory granule membrane Biological process sensory perception of umami taste calcium ion transport into cytosol regulation of cardiac conduction regulation of insulin secretion memory ion transport platelet activation response to calcium ion sensory perception of bitter taste calcium ion transmembrane transport transmembrane transport sensory perception of sweet taste inositol phosphate-mediated signaling calcium ion transport long-term potentiation G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein homooligomerization protein heterooligomerization release of sequestered calcium ion into cytosol transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3710 16440 Ensembl ENSG00000096433 ENSMUSG00000042644 UniProt Q14573 P70227 RefSeq (mRNA) NM_002224 NM_080553 RefSeq (protein) NP_002215 NP_542120 Location (UCSC) Chr 6: 33.62 – 33.7 Mb Chr 17: 27.28 – 27.34 Mb PubMed search [3] [4]
Wikidata
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Function

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.^[7]

See also

• Inositol trisphosphate receptor