Intersectin 1

Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.^[5][6]

ITSN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KI1, 2KGR, 2KHN, 3QBV, 4IIM
Identifiers
Aliases	ITSN1, ITSN, SH3D1A, SH3P17, intersectin 1
External IDs	OMIM: 602442; MGI: 1338069; HomoloGene: 2277; GeneCards: ITSN1; OMA:ITSN1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,642,400 bp[1] End 33,899,861 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 91,526,169 bp[2] End 91,717,485 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve tibia saphenous vein parietal pleura optic nerve adipose tissue pericardium subcutaneous adipose tissue abdominal fat ganglionic eminence Top expressed in Rostral migratory stream ciliary body genital tubercle tail of embryo primitive streak cumulus cell sciatic nerve dentate gyrus of hippocampal formation granule cell stroma of bone marrow masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding protein binding kinase activator activity molecular adaptor activity proline-rich region binding guanyl-nucleotide exchange factor activity Cellular component cytosol cell projection membrane plasma membrane endocytic vesicle synapse cell junction neuron projection clathrin-coated pit endomembrane system lamellipodium calyx of Held presynaptic endocytic zone nucleus nuclear envelope cytoplasm endosome cytoplasmic vesicle recycling endosome soma dendritic spine apical dendrite intracellular vesicle postsynaptic actin cytoskeleton glutamatergic synapse Biological process negative regulation of neuron apoptotic process positive regulation of protein kinase B signaling intracellular signal transduction endocytosis ephrin receptor signaling pathway synaptic vesicle endocytosis positive regulation of apoptotic process positive regulation of phosphorylation regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction small GTPase mediated signal transduction membrane organization viral process G protein-coupled receptor signaling pathway positive regulation of kinase activity exocytosis protein transport brain development positive regulation of growth hormone secretion positive regulation of dendritic spine development regulation of modification of postsynaptic actin cytoskeleton positive regulation of caveolin-mediated endocytosis positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6453 16443 Ensembl ENSG00000205726 ENSMUSG00000022957 UniProt Q15811 Q6J334 Q9Z0R4 RefSeq (mRNA) NM_001001132 NM_003024 NM_001331008 NM_001331009 NM_001331010 NM_001331011 NM_001331012 NM_001110275 NM_001110276 NM_010587 RefSeq (protein) NP_001001132 NP_001317937 NP_001317938 NP_001317939 NP_001317940 NP_001317941 NP_003015 NP_001103745 NP_001103746 NP_034717 Location (UCSC) Chr 21: 33.64 – 33.9 Mb Chr 16: 91.53 – 91.72 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.^[7]

Interactions

ITSN1 has been shown to interact with:

• CDC42,^[8][9]
• SCAMP1^[10]
• SNAP-25,^[11] and
• SOS1.^[12]