SCAMP1

Secretory carrier-associated membrane protein 1 is a protein that in humans is encoded by the SCAMP1 gene.^[5][6]

SCAMP1
Identifiers
Aliases	SCAMP1, SCAMP, SCAMP37, secretory carrier membrane protein 1
External IDs	OMIM: 606911; MGI: 1349480; HomoloGene: 37975; GeneCards: SCAMP1; OMA:SCAMP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 78,360,611 bp[1] End 78,480,739 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 94,337,818 bp[2] End 94,422,365 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium Epithelium of choroid plexus lateral nuclear group of thalamus superior vestibular nucleus Brodmann area 23 islet of Langerhans secondary oocyte buccal mucosa cell cartilage tissue seminal vesicula Top expressed in ventral tegmental area habenula olfactory tubercle dorsomedial hypothalamic nucleus dorsal tegmental nucleus spermatid paraventricular nucleus of hypothalamus globus pallidus seminal vesicula medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane integral component of membrane endosome recycling endosome membrane trans-Golgi network Golgi apparatus synapse synaptic vesicle membrane zymogen granule membrane clathrin-coated vesicle plasma membrane specific granule membrane cytoplasmic vesicle membrane Golgi membrane trans-Golgi network membrane Biological process protein transport post-Golgi vesicle-mediated transport exocytosis neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9522 107767 Ensembl ENSG00000085365 ENSMUSG00000021687 UniProt O15126 Q8K021 RefSeq (mRNA) NM_001290229 NM_004866 NM_052822 NM_029153 NM_001346609 RefSeq (protein) NP_001277158 NP_004857 NP_001333538 NP_083429 Location (UCSC) Chr 5: 78.36 – 78.48 Mb Chr 13: 94.34 – 94.42 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways.^[6]

Interactions

SCAMP1 has been shown to interact with ITSN1^[7] and AP1GBP1.^[7]