IgA pemphigus

IgA pemphigus is a subtype of pemphigus with two distinct forms:

• Subcorneal pustular dermatosis (also known as Sneddon–Wilkinson disease and pustulosis subcornealis)^[1] is skin condition that is a rare, chronic, recurrent, pustular eruption characterized histopathologically by subcorneal pustules that contain abundant neutrophils.^{[2][3]: 203} This is distinct from and not to be confused with subcorneal pustular dermatosis type of IgA pemphigus. Sneddon's syndrome, also known as Ehrmann-Sneddon syndrome, is also a different syndrome.^[4]
• Intraepidermal neutrophilic IgA dermatosis is characterized histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis.^[3]: 465

IgA pemphigus
Schematic of immunoglobulin A dimer showing H-chain (blue), L-chain (red), J-chain (magenta) and secretory component (yellow).
Specialty	Dermatology

History

Early descriptions were made by Darrell Wilkinson, a British dermatologist.^[5]

See also

• Pemphigus
• List of target antigens in pemphigus
• List of conditions caused by problems with junctional proteins
• List of immunofluorescence findings for autoimmune bullous conditions