List of target antigens in pemphigus

See also: List of cutaneous conditions

This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

Target antigens for the different pemphigus variants

Pemphigus variant	Antibody isotype	Antigen	Molecular weight (KDa)
Mucosal pemphigus vulgaris	IgG	Desmoglein 3	130
Mucocutaneous pemphigus vulgaris	IgG	Desmoglein 3 Desmoglein 1	130 160
Pemphigus foliaceus	IgG	Desmoglein 1	160
Paraneoplastic pemphigus	IgG	Desmoglein 3 Desmoglein 1 BPAG1[nb 1] Plectin Desmoplakin I[nb 2] Desmoplakin II Envoplakin Periplakin Alpha-2-macroglobulin-like-1	130 160 230 500 250 210 210 190 170
Drug-induced pemphigus	IgG	Desmoglein 3 Desmoglein 1	130 160
Subcorneal pustular dermatosis type of IgA pemphigus	IgA1	Desmocollin 1	110/100
Intraepidermal neutrophilic type of IgA pemphigus	IgA1	Unknown
Pemphigus erythematosus (Senear–Usher syndrome)[nb 3]	IgG	Desmoglein 1	160
Fogo selvagem	IgG	Desmoglein 1	160
Pemphigus vegetans	IgG	Desmoglein 3	130
Pemphigus vegetans of Hallopeau[nb 4]	IgG	Desmoglein 3	130
Pemphigus vegetans of Neumann[nb 4]	IgG	Desmoglein 3	130
Pemphigus herpetiformis	IgG	Desmoglein 3 Desmoglein 1	130 160

Footnotes

1. Notably not BPAG2
2. Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome
3. Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
4. Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.

See also

• List of target antigens in pemphigoid
• List of conditions caused by problems with junctional proteins
• List of immunofluorescence findings for autoimmune bullous conditions
• List of cutaneous conditions
• List of genes mutated in cutaneous conditions
• List of histologic stains that aid in diagnosis of cutaneous conditions