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Integrin alpha 2

Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia

Integrin alpha 2
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Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.

Quick Facts ITGA2, Available structures ...

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.[5]

Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.[6]

The DX5 monoclonal antibody recognizes mouse CD49b.[7]

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Interactions

CD49b has been shown to interact with MMP1.[8][9]

References

Further reading

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