Integrin alpha 9

Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene.^[5][6][7] Cytogenetic location: 3p22.2 ^[8]

ITGA9
Identifiers
Aliases	ITGA9, ALPHA-RLC, ITGA4L, RLC, integrin subunit alpha 9
External IDs	OMIM: 603963; MGI: 104756; HomoloGene: 1664; GeneCards: ITGA9; OMA:ITGA9 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 37,452,115 bp[1] End 37,823,507 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F3|9 70.32 cM Start 118,435,758 bp[2] End 118,730,071 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urethra saphenous vein visceral pleura right ventricle Descending thoracic aorta tendon of biceps brachii vena cava ascending aorta thyroid gland right lobe of thyroid gland Top expressed in zygote ascending aorta secondary oocyte primary oocyte aortic valve Gonadal ridge external carotid artery internal carotid artery genital tubercle interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding laminin binding collagen binding Cellular component integrin complex basal plasma membrane plasma membrane membrane integrin alpha9-beta1 complex integral component of membrane Biological process wound healing integrin-mediated signaling pathway extracellular matrix organization neutrophil chemotaxis cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3680 104099 Ensembl ENSG00000144668 ENSMUSG00000039115 UniProt Q13797 B8JK39 RefSeq (mRNA) NM_002207 NM_001113514 NM_133721 RefSeq (protein) NP_002198 NP_001106986 NP_598482 Location (UCSC) Chr 3: 37.45 – 37.82 Mb Chr 9: 118.44 – 118.73 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for tenascin-C, VCAM1 and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.^[7]

Interactions

The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell adhesion with various ligands in the extracellular matrix (ECM), including extra domain A (EDA) fibronectin, tenascin-C, ADAMs, EMELIN1, osteopontin, and VEGF.^[9] α9β1 binding is independent of the RGD peptide sequence.