Intercellular adhesion molecule

In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.^[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces.

Intercellular adhesion molecule (ICAM), N-terminal domain
structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1
Identifiers
Symbol	ICAM_N
Pfam	PF03921
Pfam clan	CL0159
InterPro	IPR013768
SCOP2	1zxq / SCOPe / SUPFAM
Membranome	219
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Mammalian intercellular adhesion molecules include:

• ICAM-1
• ICAM2
• ICAM3
• ICAM4
• ICAM5