ICAM2

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

ICAM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZXQ
Identifiers
Aliases	ICAM2, CD102, intercellular adhesion molecule 2
External IDs	OMIM: 146630; MGI: 96394; HomoloGene: 675; GeneCards: ICAM2; OMA:ICAM2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 64,002,594 bp[1] End 64,020,634 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 69.09 cM Start 106,268,482 bp[2] End 106,278,901 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen granulocyte vena cava pericardium apex of heart right lung upper lobe of lung upper lobe of left lung abdominal fat lower lobe of lung Top expressed in right lung lobe left lung left lung lobe thymus endocardial cushion atrioventricular valve carotid body dermis external carotid artery renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding Cellular component integral component of membrane plasma membrane uropod extracellular exosome membrane cell periphery integral component of plasma membrane cleavage furrow microvillus cell projection Biological process cell adhesion stimulatory C-type lectin receptor signaling pathway extracellular matrix organization regulation of immune response cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3384 15896 Ensembl ENSG00000108622 ENSMUSG00000001029 UniProt P13598 P35330 RefSeq (mRNA) NM_001099789 NM_000873 NM_001099786 NM_001099787 NM_001099788 NM_010494 RefSeq (protein) NP_000864 NP_001093256 NP_001093257 NP_001093258 NP_001093259 NP_034624 Location (UCSC) Chr 17: 64 – 64.02 Mb Chr 11: 106.27 – 106.28 Mb PubMed search [3] [4]
Wikidata
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Protein structure

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions

ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.^[5]

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.^[6]

Interactions

ICAM2 has been shown to interact with EZR.^[7] It has also been shown to bind to P9 (Uniprot: B2UM07), a secreted protein from Akkermansia muciniphila.^[8]

See also

• Cluster of differentiation