Interferon gamma receptor 1

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.^[5][6][7]

IFNGR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FG9, 1FYH, 1JRH
Identifiers
Aliases	IFNGR1, CD119, IFNGR, IMD27A, IMD27B, interferon gamma receptor 1
External IDs	OMIM: 107470; MGI: 107655; HomoloGene: 359; GeneCards: IFNGR1; OMA:IFNGR1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 137,197,483 bp[1] End 137,219,449 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A3|10 8.49 cM Start 19,467,697 bp[2] End 19,485,977 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung epithelium of nasopharynx right lung jejunal mucosa pericardium human penis palpebral conjunctiva skin of hip monocyte upper lobe of lung Top expressed in lower jaw Meckel's cartilage mandibular molars thymus left colon granulocyte myometrium duodenum tibiofemoral joint lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interferon-gamma receptor activity protein binding cytokine binding cytokine receptor activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane Biological process response to virus regulation of interferon-gamma-mediated signaling pathway signal transduction interferon-gamma-mediated signaling pathway cytokine-mediated signaling pathway microglial cell activation positive regulation of gene expression astrocyte activation negative regulation of amyloid-beta clearance positive regulation of amyloid-beta formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3459 15979 Ensembl ENSG00000027697 ENSMUSG00000020009 UniProt P15260 P15261 RefSeq (mRNA) NM_000416 NM_001363526 NM_001363527 NM_010511 RefSeq (protein) NP_000407 NP_001350455 NP_001350456 NP_034641 Location (UCSC) Chr 6: 137.2 – 137.22 Mb Chr 10: 19.47 – 19.49 Mb PubMed search [3] [4]
Wikidata
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Function

The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.^[5]

Interactions

Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.^[8][9]

Mutations

Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections.^[10][11] All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.^[12][13]

See also

• Cluster of differentiation
• Interferon-gamma receptor