Interleukin-7 receptor-α

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.^[5][6]

IL7R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DI2, 3DI3, 3UP1
Identifiers
Aliases	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDs	OMIM: 146661; MGI: 96562; HomoloGene: 1646; GeneCards: IL7R; OMA:IL7R - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 35,852,695 bp[1] End 35,879,603 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 4.16 cM Start 9,505,874 bp[2] End 9,530,262 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung granulocyte lymph node lower lobe of lung epithelium of nasopharynx appendix blood thymus upper lobe of left lung gallbladder Top expressed in blood mesenteric lymph nodes spleen thymus tibiofemoral joint subcutaneous adipose tissue bone marrow Paneth cell pharynx lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding interleukin-7 receptor activity protein binding cytokine receptor activity Cellular component integral component of membrane membrane plasma membrane extracellular region external side of plasma membrane clathrin-coated vesicle membrane Biological process regulation of cell size regulation of DNA recombination positive regulation of T cell differentiation in thymus homeostasis of number of cells negative regulation of T cell mediated cytotoxicity cell surface receptor signaling pathway B cell proliferation T cell differentiation positive regulation of gene expression immune response cell morphogenesis lymph node development immunoglobulin production signal transduction interleukin-7-mediated signaling pathway positive regulation of cell population proliferation positive regulation of receptor signaling pathway via STAT membrane organization negative regulation of T cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3575 16197 Ensembl ENSG00000168685 ENSMUSG00000003882 UniProt P16871 P16872 RefSeq (mRNA) NM_002185 NM_008372 NM_001355680 RefSeq (protein) NP_002176 NP_032398 NP_001342609 Location (UCSC) Chr 5: 35.85 – 35.88 Mb Chr 15: 9.51 – 9.53 Mb PubMed search [3] [4]
Wikidata
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IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.