Type I cytokine receptor

Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

Type I cytokine receptor, cytokine-binding domain
Identifiers
Symbol	TypeI_recpt_CBD
Pfam	PF09240
Pfam clan	CL0159
InterPro	IPR015321
SCOP2	1n26 / SCOPe / SUPFAM
Membranome	2
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The common cytokine-binding domain is related to the Fibronectin type III domain.

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.^[1]

• The IL-2 receptor common gamma chain (also known as CD132) is shared between:
  • IL-2 receptor
  • IL-4 receptor
  • IL-7 receptor
  • IL-9 receptor
  • IL-13 receptor
  • IL-15 receptor^[2]
  • IL-21 receptor^[3]
• The common beta chain (CSF2RB, CD131, or CDw131) is shared between the following type I cytokine receptors:
  • GM-CSF receptor
  • IL-3 receptor
  • IL-5 receptor.^[4]
• The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
  • IL-6 receptor
  • IL-11 receptor
  • IL-12 receptor
  • IL-27 receptor
  • Leukemia inhibitory factor receptor
  • Oncostatin M receptor

Examples

Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors

Interleukin receptors

• Interleukin-1 receptor
• Interleukin-2 receptor
• Interleukin-3 receptor
• Interleukin-4 receptor
• Interleukin-5 receptor
• Interleukin-6 receptor
• Interleukin-7 receptor
• Interleukin-9 receptor
• Interleukin-11 receptor
• Interleukin-12 receptor
• Interleukin-13 receptor
• Interleukin-15 receptor
• Interleukin-18 receptor
• Interleukin-21 receptor
• Interleukin-23 receptor
• Interleukin-27 receptor

Colony stimulating factor receptors

• Erythropoietin receptor
• GM-CSF receptor
• G-CSF receptor
• Thrombopoietin receptor

Hormone receptor/neuropeptide receptor

• Growth hormone receptor
• Prolactin receptor
• Leptin receptor^[5]

Other

• Oncostatin M receptor
• Leukemia inhibitory factor receptor