Interleukin 10 receptor, alpha subunit

Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene.

IL10RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J7V, 1LQS, 1Y6K, 1Y6M, 1Y6N, 5IXI
Identifiers
Aliases	IL10RA, CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, Interleukin 10 receptor, alpha subunit, interleukin 10 receptor subunit alpha
External IDs	OMIM: 146933; MGI: 96538; HomoloGene: 1196; GeneCards: IL10RA; OMA:IL10RA - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 117,986,370 bp[1] End 118,003,037 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 45,165,135 bp[2] End 45,180,447 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mononuclear cell monocyte blood spleen bone marrow cells lymph node appendix gallbladder rectum Top expressed in granulocyte spleen stroma of bone marrow mesenteric lymph nodes blood embryo ankle joint thymus subcutaneous adipose tissue superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding interleukin-10 binding signal transducer activity interleukin-10 receptor activity signaling receptor activity cytokine receptor activity Cellular component integral component of membrane membrane plasma membrane cytoplasm Biological process response to lipopolysaccharide regulation of synapse organization cytokine-mediated signaling pathway negative regulation of autophagy positive regulation of receptor signaling pathway via JAK-STAT ubiquitin-dependent endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3587 16154 Ensembl ENSG00000110324 ENSMUSG00000032089 UniProt Q13651 Q61727 RefSeq (mRNA) NM_001558 NM_008348 NM_001324486 RefSeq (protein) NP_001549 NP_001311415 NP_032374 Location (UCSC) Chr 11: 117.99 – 118 Mb Chr 9: 45.17 – 45.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

IL10RA has also been designated CDw210a (cluster of differentiation w210a).

Function

See also: PI 3-kinase/AKT pathway

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.^[5]

Interactions

Interleukin 10 receptor, alpha subunit has been shown to interact with:

• Interleukin 10^{[6][7][8][9][10]} and
• Janus kinase 1.^[11][12]