Interleukin 11 receptor alpha subunit

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.^[5]

IL11RA
Identifiers
Aliases	IL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha
External IDs	OMIM: 600939; MGI: 109123; HomoloGene: 88705; GeneCards: IL11RA; OMA:IL11RA - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,652,162 bp[1] End 34,661,902 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 22.73 cM Start 42,656,001 bp[2] End 42,665,763 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart Descending thoracic aorta right auricle of heart ascending aorta granulocyte muscle layer of sigmoid colon right coronary artery right hemisphere of cerebellum left lobe of thyroid gland left uterine tube Top expressed in granular layer of epidermis spermatocyte dental follicle blood vessel third ventricle cartilage tissue tracheobronchial tree bronchus tongue dermis More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine receptor activity transmembrane signaling receptor activity signal transducer activity interleukin-11 receptor activity cytokine binding interleukin-11 binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane receptor complex Biological process head development embryo implantation developmental process cytokine-mediated signaling pathway positive regulation of cell population proliferation interleukin-11-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3590 16158 Ensembl ENSG00000137070 ENSMUSG00000078735 UniProt Q14626 P70225 RefSeq (mRNA) NM_001142784 NM_004512 NM_147162 NM_010550 RefSeq (protein) NP_001136256 NP_001092818 NP_001365603 Location (UCSC) Chr 9: 34.65 – 34.66 Mb Chr 4: 42.66 – 42.67 Mb PubMed search [3] [4]
Wikidata
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Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.^[5]