Interleukin 36 receptor antagonist

Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named Interleukin-1 family member 5 (IL1F5).^[5][6][7][8]

IL36RN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P0J, 4P0K, 4P0L
Identifiers
Aliases	IL36RN, FIL1, FIL1(DELTA), FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, IL-36Ra, PSORS14, interleukin 36 receptor antagonist
External IDs	OMIM: 605507; MGI: 1859325; HomoloGene: 10453; GeneCards: IL36RN; OMA:IL36RN - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 113,058,638 bp[1] End 113,065,382 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 16.31 cM Start 24,166,966 bp[2] End 24,173,438 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid skin of arm gums gingival epithelium skin of leg skin of abdomen cervix epithelium oral cavity buccal mucosa cell cartilage tissue Top expressed in lip esophagus skin of external ear skin of back umbilical cord skin of abdomen parotid gland superior surface of tongue lumbar subsegment of spinal cord epidermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity protein binding interleukin-1 receptor binding interleukin-1 receptor antagonist activity Cellular component extracellular space extracellular region Biological process negative regulation of interleukin-6 production negative regulation of cytokine-mediated signaling pathway innate immune response negative regulation of interleukin-17 production antifungal humoral response immune system process inflammatory response immune response regulation of signaling receptor activity cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26525 54450 Ensembl ENSG00000136695 ENSMUSG00000026983 UniProt Q9UBH0 Q9QYY1 RefSeq (mRNA) NM_173170 NM_012275 NM_001146087 NM_001146088 NM_019451 RefSeq (protein) NP_036407 NP_775262 NP_001139559 NP_001139560 NP_062324 Location (UCSC) Chr 2: 113.06 – 113.07 Mb Chr 2: 24.17 – 24.17 Mb PubMed search [3] [4]
Wikidata
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The protein is known to inhibit the effects of Interleukin-36 cytokines (IL-36α, IL-36β and IL-36γ) via competing with their receptor IL-36R/IL1RL2 and thereby inhibiting their proinflammatory effects.^[9]

Roles in disease

Mutations in the IL-36RN gene resulting in a decrease or production of defective IL-36RA protein have been shown to cause inflammatory skin diseases including generalised pustular psoriasis, acrodermatitis continua suppurativa Hallopeau (ACH) and acute generalized exanthematous pustulosis (AGEP).^[10]