Interleukin 8 receptor, alpha

Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1. It has also been designated as CD181 (cluster of differentiation 181). The IUPHAR Committee on Receptor Nomenclature and Drug Classification use the HGNC recommended name, CXCR1.

CXCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ILP, 1ILQ, 2LNL
Identifiers
Aliases	CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA, Interleukin 8 receptor, C-X-C motif chemokine receptor 1
External IDs	OMIM: 146929; MGI: 2448715; HomoloGene: 68074; GeneCards: CXCR1; OMA:CXCR1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,162,841 bp[1] End 218,166,962 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 38.44 cM Start 74,230,944 bp[2] End 74,233,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte periodontal fiber spleen bone marrow bone marrow cells appendix right lung upper lobe of left lung nasal epithelium Top expressed in granulocyte blastocyst placenta lung zone of skin More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-X-C chemokine receptor activity interleukin-8 binding G protein-coupled receptor activity chemokine receptor activity interleukin-8 receptor activity signal transducer activity C-C chemokine receptor activity chemokine binding C-C chemokine binding Cellular component integral component of membrane plasma membrane secretory granule membrane membrane external side of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway receptor internalization dendritic cell chemotaxis signal transduction chemokine-mediated signaling pathway interleukin-8-mediated signaling pathway neutrophil degranulation chemotaxis immune response positive regulation of cytosolic calcium ion concentration calcium-mediated signaling neutrophil chemotaxis cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3577 227288 Ensembl ENSG00000163464 ENSMUSG00000048480 UniProt P25024 Q810W6 RefSeq (mRNA) NM_000634 NM_178241 RefSeq (protein) NP_000625 NP_839972 Location (UCSC) Chr 2: 218.16 – 218.17 Mb Chr 1: 74.23 – 74.23 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. IL8RA, IL8RB, which encodes another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.^[5] Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8, leads to neutrophil chemotaxis and activation.^[6]

Clinical significance

Blocking CXCR1 (e.g., with repertaxin^[7]) inhibits some human breast cancer stem cells (in vitro and in mice).^[8]

In malignant melanoma expression of CXCR1 at the cell surface is present, independent of the cancers stage. It is thought to have a role in the cell growth and angiogenesis required for tumour survival. In this way it has been identified as a potential therapeutic target.^[9]

CXCR1 can be cleaved and inactivated by Neutrophil Derived Serine Proteases (NSPs), leading to neutrophil dysfunction and impaired bacterial killing in cystic fibrosis lung disease.^[10]

Interactions

Interleukin 8 receptor, alpha has been shown to interact with GNAI2.^[11][12]

See also

• Interleukin
• Interleukin 8
• Interleukin 8 receptor, beta
• Interleukin receptor
• Interleukin-8 receptor