JAG2

Jagged-2 is a protein that in humans is encoded by the JAG2 gene.^[5][6][7]

JAG2
Identifiers
Aliases	JAG2, HJ2, SER2, jagged 2, jagged canonical Notch ligand 2, LGMDR27
External IDs	OMIM: 602570; MGI: 1098270; HomoloGene: 1677; GeneCards: JAG2; OMA:JAG2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 105,140,982 bp[1] End 105,168,824 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 61.37 cM Start 112,871,439 bp[2] End 112,893,396 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple apex of heart pituitary gland skin of abdomen anterior pituitary skin of leg skin of thigh endothelial cell olfactory zone of nasal mucosa right frontal lobe Top expressed in lip primary oocyte molar secondary oocyte esophagus superior frontal gyrus corneal stroma hair follicle muscle of thigh external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Notch binding protein binding growth factor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process Notch signaling pathway skeletal system development respiratory system process epithelial cell apoptotic process involved in palatal shelf morphogenesis in utero embryonic development multicellular organism development odontogenesis of dentin-containing tooth cell communication auditory receptor cell fate commitment T cell differentiation regulation of cell adhesion spermatogenesis morphogenesis of embryonic epithelium gamma-delta T cell differentiation thymic T cell selection positive regulation of Notch signaling pathway cell differentiation regulation of cell population proliferation regulation of signaling receptor activity negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3714 16450 Ensembl ENSG00000184916 ENSMUSG00000002799 UniProt Q9Y219 Q9QYE5 RefSeq (mRNA) NM_002226 NM_145159 NM_010588 RefSeq (protein) NP_002217 NP_660142 NP_034718 Location (UCSC) Chr 14: 105.14 – 105.17 Mb Chr 12: 112.87 – 112.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

JAG2 has been shown to interact with NOTCH2.^[8]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.^[9]