JUNB

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene.^[5][6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

JUNB
Identifiers
Aliases	JUNB, AP-1, JunB proto-oncogene, AP-1 transcription factor subunit
External IDs	OMIM: 165161; MGI: 96647; HomoloGene: 7390; GeneCards: JUNB; OMA:JUNB - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,791,486 bp[1] End 12,793,315 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C3|8 41.41 cM Start 85,701,113 bp[2] End 85,705,347 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa left uterine tube granulocyte monocyte tibial arteries vena cava saphenous vein left ovary nipple trachea Top expressed in granulocyte lip superior surface of tongue spermatid spermatocyte corneal stroma visual cortex esophagus transitional epithelium of urinary bladder primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm chromatin nucleus transcription factor AP-1 complex transcription regulator complex Biological process cellular response to calcium ion regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of cell death osteoclast differentiation labyrinthine layer blood vessel development in utero embryonic development negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of cell cycle vasculogenesis embryonic process involved in female pregnancy response to lipopolysaccharide decidualization regulation of cell population proliferation trophectodermal cell differentiation osteoblast differentiation positive regulation of cell differentiation response to radiation osteoblast proliferation cellular process or phenomenon response to cAMP response to mechanical stimulus transcription, DNA-templated cellular response to hormone stimulus response to cytokine positive regulation of transcription by RNA polymerase II cytokine-mediated signaling pathway response to organic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3726 16477 Ensembl ENSG00000171223 ENSMUSG00000052837 UniProt P17275 P09450 RefSeq (mRNA) NM_002229 NM_008416 RefSeq (protein) NP_002220 NP_032442 Location (UCSC) Chr 19: 12.79 – 12.79 Mb Chr 8: 85.7 – 85.71 Mb PubMed search [3] [4]
Wikidata
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Interactions

JUNB has been shown to interact with

• BRCA1,^[7] and
• SMAD3.^[8]

See also

• AP-1 (transcription factor)