JunD

For the military districts under the early Caliphates, see Jund.

Transcription factor JunD is a protein that in humans is encoded by the JUND gene.^[5][6]

JUND
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U86
Identifiers
Aliases	JUND, AP-1, JunD, JunD proto-oncogene, AP-1 transcription factor subunit
External IDs	OMIM: 165162; MGI: 96648; HomoloGene: 3910; GeneCards: JUND; OMA:JUND - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,279,694 bp[1] End 18,281,622 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.15 cM Start 71,151,599 bp[2] End 71,153,265 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardia vena cava nipple paraflocculus of cerebellum pylorus renal medulla lactiferous duct trachea saphenous vein Brodmann area 10 Top expressed in granulocyte adrenal gland bone marrow islet of Langerhans ileum ganglionic eminence cerebellar cortex primary visual cortex striatum of neuraxis urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity transcription coactivator activity protein binding enzyme binding double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific nuclear receptor binding Cellular component protein-DNA complex chromatin nucleus transcription factor AP-1 complex protein-containing complex nucleoplasm transcription regulator complex Biological process cellular response to calcium ion response to cytokine regulation of transcription, DNA-templated response to organic cyclic compound response to light stimulus regulation of cell death ageing response to peptide hormone negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated regulation of cell cycle cellular response to hormone stimulus positive regulation of osteoblast differentiation regulation of cell population proliferation circadian rhythm positive regulation of cell differentiation osteoblast development response to radiation response to cAMP response to lipopolysaccharide response to mechanical stimulus regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II response to organic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3727 16478 Ensembl ENSG00000130522 ENSMUSG00000071076 UniProt P17535 P15066 RefSeq (mRNA) NM_005354 NM_001286968 NM_001286944 NM_010592 RefSeq (protein) NP_001273897 NP_005345 NP_001273873 NP_034722 Location (UCSC) Chr 19: 18.28 – 18.28 Mb Chr 8: 71.15 – 71.15 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.^[7]

ΔJunD

The dominant negative mutant variant of JunD, known as ΔJunD or Delta JunD, is a potent antagonist of the ΔFosB transcript, as well as other forms of AP-1-mediated transcriptional activity.^[8][9][10] In the nucleus accumbens, ΔJunD directly opposes many of the neurological changes that occur in addiction (i.e., those induced by ΔFosB).^[9][10] ΔFosB inhibitors (drugs that oppose its action) may be an effective treatment for addiction and addictive disorders.^[11] Being an unnatural genetic variant, deltaJunD has not been observed in humans.

Interactions

JunD has been shown to interact with ATF3,^[12] MEN1,^[13] DNA damage-inducible transcript 3^[14] and BRCA1.^[15]

See also

• AP-1 (transcription factor)