KATNA1

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.^[5][6]

KATNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPA
Identifiers
Aliases	KATNA1, katanin catalytic subunit A1
External IDs	OMIM: 606696; MGI: 1344353; HomoloGene: 56014; GeneCards: KATNA1; OMA:KATNA1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 149,594,873 bp[1] End 149,648,972 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 7,601,764 bp[2] End 7,638,914 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte gonad left testis right testis Achilles tendon retinal pigment epithelium testicle gastrocnemius muscle Descending thoracic aorta Top expressed in granulocyte epiblast bone marrow zygote zone of skin ileum primary oocyte thymus secondary oocyte esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding microtubule binding microtubule-severing ATPase activity protein binding protein heterodimerization activity hydrolase activity ATP binding ATPase activity isomerase activity Cellular component cytoplasm spindle pole midbody microtubule cytoskeleton nucleus microtubule organizing center spindle mitotic spindle pole centrosome Biological process cell division microtubule severing cell cycle cytoplasmic microtubule organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11104 23924 Ensembl ENSG00000186625 ENSMUSG00000019794 UniProt O75449 Q9WV86 RefSeq (mRNA) NM_001204076 NM_007044 NM_011835 RefSeq (protein) NP_001191005 NP_008975 n/a Location (UCSC) Chr 6: 149.59 – 149.65 Mb Chr 10: 7.6 – 7.64 Mb PubMed search [3] [4]
Wikidata
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Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.^[6]