KCNA5

Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or K_v1.5, is a protein that in humans is encoded by the KCNA5 gene.^[5]

KCNA5
Identifiers
Aliases	KCNA5, ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1, potassium voltage-gated channel subfamily A member 5
External IDs	OMIM: 176267; MGI: 96662; HomoloGene: 1683; GeneCards: KCNA5; OMA:KCNA5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.32 Start 5,043,879 bp[1] End 5,046,788 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 61.35 cM Start 126,509,514 bp[2] End 126,512,375 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium right auricle of heart right coronary artery popliteal artery tibial arteries testicle Epithelium of choroid plexus ascending aorta left coronary artery Descending thoracic aorta Top expressed in olfactory epithelium epithelium of lens trigeminal nerve retina endocardial cushion olfactory tubercle neural layer of retina renal pelvis nucleus accumbens myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel inhibitor activity outward rectifier potassium channel activity potassium channel activity scaffold protein binding voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in SA node cell action potential repolarization delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization voltage-gated ion channel activity ion channel activity protein binding alpha-actinin binding voltage-gated potassium channel activity signaling receptor binding protein kinase binding Cellular component integral component of membrane Golgi apparatus membrane intercalated disc intracellular canaliculus voltage-gated potassium channel complex plasma membrane integral component of plasma membrane potassium channel complex Z discdkac endoplasmic reticulum perinuclear region of cytoplasm caveola membrane raft cell surface Biological process Notch signaling pathway regulation of atrial cardiac muscle cell membrane repolarization positive regulation of myoblast proliferation regulation of potassium ion transport response to hypoxia membrane hyperpolarization regulation of insulin secretion response to hyperoxia regulation of membrane potential regulation of ion transmembrane transport response to mechanical stimulus ion transport response to organic substance membrane repolarization during bundle of His cell action potential positive regulation of G1/S transition of mitotic cell cycle potassium ion transport regulation of vasoconstriction potassium ion homeostasis protein complex oligomerization transmembrane transport potassium ion transmembrane transport negative regulation of potassium ion transport atrial cardiac muscle cell action potential membrane repolarization during SA node cell action potential regulation of heart rate by cardiac conduction protein homooligomerization response to hydrogen peroxide negative regulation of cytosolic calcium ion concentration membrane repolarization during atrial cardiac muscle cell action potential regulation of molecular function transport potassium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3741 16493 Ensembl ENSG00000130037 ENSMUSG00000045534 UniProt P22460 Q61762 RefSeq (mRNA) NM_002234 NM_145983 RefSeq (protein) NP_002225 NP_666095 Location (UCSC) Chr 12: 5.04 – 5.05 Mb Chr 6: 126.51 – 126.51 Mb PubMed search [3] [4]
Wikidata
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Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.^[5] Mutations in this gene have been related to both atrial fibrillation^[6] and sudden cardiac death.^[7] KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Interactions

KCNA5 has been shown to interact with DLG4,^[8][9] PDZ domain-containing proteins such as SAP97,^[10] and Actinin, alpha 2.^[8][11]

See also

• Voltage-gated potassium channel