KCNAB1

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.^[5][6][7]

KCNAB1
Identifiers
Aliases	KCNAB1, AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3, potassium voltage-gated channel subfamily A member regulatory beta subunit 1, potassium voltage-gated channel subfamily A regulatory beta subunit 1
External IDs	OMIM: 601141; MGI: 109155; HomoloGene: 56491; GeneCards: KCNAB1; OMA:KCNAB1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.31 Start 156,037,701 bp[1] End 156,539,138 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E1|3 30.15 cM Start 64,856,617 bp[2] End 65,285,644 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus tibial arteries urethra putamen saphenous vein caudate nucleus Brodmann area 23 Region I of hippocampus proper nucleus accumbens tail of epididymis Top expressed in olfactory tubercle facial motor nucleus medial dorsal nucleus nucleus accumbens globus pallidus dentate gyrus of hippocampal formation granule cell lobe of cerebellum superior frontal gyrus Region I of hippocampus proper anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aldo-keto reductase (NADP) activity voltage-gated ion channel activity potassium channel regulator activity NADPH binding voltage-gated potassium channel activity oxidoreductase activity protein domain specific binding transmembrane transporter binding Cellular component cytoplasm integral component of membrane cytosol perikaryon membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane axon soma proximal dendrite potassium channel complex dendrite cytoplasm juxtaparanode region of axon voltage-gated potassium channel complex Biological process diaphragm development regulation of ion transmembrane transport ion transport potassium ion transport heart development brain development regulation of delayed rectifier potassium channel activity transmembrane transport regulation of potassium ion transmembrane transporter activity potassium ion transmembrane transport learning or memory myoblast differentiation skeletal muscle tissue development regulation of potassium ion transmembrane transport negative regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7881 16497 Ensembl ENSG00000169282 ENSMUSG00000027827 UniProt Q14722 Q5MJQ3 P63143 RefSeq (mRNA) NM_001308217 NM_001308222 NM_003471 NM_172159 NM_172160 NM_001289450 NM_010597 NM_001357358 RefSeq (protein) NP_001295146 NP_001295151 NP_003462 NP_751891 NP_751892 NP_001295151.1 NP_001276379 NP_034727 NP_001344287 Location (UCSC) Chr 3: 156.04 – 156.54 Mb Chr 3: 64.86 – 65.29 Mb PubMed search [3] [4]
Wikidata
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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms that are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.^[7]

See also

• Voltage-gated potassium channel