KCNC3

Potassium voltage-gated channel, Shaw-related subfamily, member 3 also known as KCNC3 or K_v3.3 is a protein that in humans is encoded by the KCNC3.^[5]

KCNC3
Identifiers
Aliases	KCNC3, KSHIIID, KV3.3, SCA13, potassium voltage-gated channel subfamily C member 3
External IDs	OMIM: 176264; MGI: 96669; HomoloGene: 3650; GeneCards: KCNC3; OMA:KCNC3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,311,937 bp[1] End 50,333,515 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.85 cM Start 44,590,664 bp[2] End 44,604,754 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube cerebellar vermis right hemisphere of cerebellum left lobe of thyroid gland right lobe of thyroid gland vena cava lateral nuclear group of thalamus pons inferior ganglion of vagus nerve external globus pallidus Top expressed in cerebellar cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus aortic arch pontine nuclei cerebellar vermis primary visual cortex lobe of cerebellum deep cerebellar nuclei lumbar subsegment of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity ion channel activity potassium channel activity voltage-gated ion channel activity delayed rectifier potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane cytoplasm cytoskeleton cell cortex cell junction axon dendrite dendritic spine membrane presynaptic membrane cell projection perikaryon synapse dendrite membrane neuronal cell body membrane soma Biological process potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport protein tetramerization transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3748 16504 Ensembl ENSG00000131398 ENSMUSG00000062785 UniProt Q14003 Q63959 RefSeq (mRNA) NM_004977 NM_001372305 NM_001290682 NM_008422 RefSeq (protein) NP_004968 NP_001359234 NP_001277611 NP_001372554 NP_001372555 NP_001372556 NP_001372557 NP_001372558 NP_001372559 NP_001372560 NP_001372561 NP_001372562 NP_001372563 NP_001372564 NP_001372565 NP_001372566 NP_032448 Location (UCSC) Chr 19: 50.31 – 50.33 Mb Chr 7: 44.59 – 44.6 Mb PubMed search [3] [4]
Wikidata
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Function

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.^[6][7][8]

Clinical significance

KCNC3 is associated with spinocerebellar ataxia type 13.^[9]

See also

• Voltage-gated potassium channel