KCNC4

For the CBS affiliate in Denver, Colorado on channel 4, see KCNC-TV.

Potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), also known as K_v3.4, is a human gene.^[5]

KCNC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B4G, 1B4I, 1ZTN
Identifiers
Aliases	KCNC4, C1orf30, HKSHIIIC, KSHIIIC, KV3.4, potassium voltage-gated channel subfamily C member 4
External IDs	OMIM: 176265; MGI: 96670; HomoloGene: 68427; GeneCards: KCNC4; OMA:KCNC4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 110,210,314 bp[1] End 110,283,100 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.3|3 46.83 cM Start 107,345,619 bp[2] End 107,366,868 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe cingulate gyrus prefrontal cortex anterior cingulate cortex right hemisphere of cerebellum amygdala dorsolateral prefrontal cortex Brodmann area 9 hypothalamus gonad Top expressed in olfactory epithelium motor neuron vastus lateralis muscle facial motor nucleus muscle of thigh triceps brachii muscle tibialis anterior muscle dentate gyrus of hippocampal formation granule cell skeletal muscle tissue masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding Cellular component plasma membrane neuromuscular junction axon terminus voltage-gated potassium channel complex membrane integral component of membrane axon dendrite membrane neuronal cell body membrane soma Biological process chemical synaptic transmission regulation of ion transmembrane transport regulation of neurotransmitter secretion protein homooligomerization potassium ion transmembrane transport potassium ion transport ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3749 99738 Ensembl ENSG00000116396 ENSMUSG00000027895 UniProt Q03721 Q8R1C0 RefSeq (mRNA) NM_001039574 NM_004978 NM_153763 NM_001377330 NM_001377331 NM_145922 NM_001356447 RefSeq (protein) NP_001034663 NP_004969 NP_001364259 NP_001364260 NP_666034 NP_001343376 Location (UCSC) Chr 1: 110.21 – 110.28 Mb Chr 3: 107.35 – 107.37 Mb PubMed search [3] [4]
Wikidata
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The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene.^[5]

See also

• Voltage-gated potassium channel