KCNIP2

K_v channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.^[5][6]

KCNIP2
Identifiers
Aliases	KCNIP2, KCHIP2, potassium voltage-gated channel interacting protein 2
External IDs	OMIM: 604661; MGI: 2135916; HomoloGene: 23710; GeneCards: KCNIP2; OMA:KCNIP2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 101,825,974 bp[1] End 101,843,920 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 38.75 cM Start 45,780,278 bp[2] End 45,804,500 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right auricle of heart nucleus accumbens caudate nucleus putamen right frontal lobe left ventricle anterior cingulate cortex cardiac muscle tissue of right atrium right hemisphere of cerebellum Top expressed in interventricular septum olfactory tubercle dentate gyrus lateral septal nucleus superior frontal gyrus dentate gyrus of hippocampal formation granule cell nucleus accumbens primary visual cortex anterior amygdaloid area myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding potassium channel activity ER retention sequence binding transmembrane transporter binding protein N-terminus binding metal ion binding voltage-gated ion channel activity protein binding A-type (transient outward) potassium channel activity identical protein binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization potassium channel regulator activity Cellular component cytoplasm membrane plasma membrane potassium channel complex voltage-gated potassium channel complex Biological process clustering of voltage-gated potassium channels muscle contraction regulation of heart contraction regulation of ion transmembrane transport ion transport detection of calcium ion potassium ion transport membrane repolarization regulation of cation channel activity potassium ion transmembrane transport regulation of potassium ion transmembrane transport signal transduction chemical synaptic transmission membrane repolarization during cardiac muscle cell action potential potassium ion export across plasma membrane positive regulation of potassium ion export across plasma membrane positive regulation of voltage-gated potassium channel activity cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30819 80906 Ensembl ENSG00000120049 ENSMUSG00000025221 UniProt Q9NS61 Q9JJ69 RefSeq (mRNA) NM_014591 NM_173191 NM_173192 NM_173193 NM_173194 NM_173195 NM_173197 NM_173342 NM_001276358 NM_030716 NM_145703 NM_145704 RefSeq (protein) NP_055406 NP_775283 NP_775284 NP_775285 NP_775286 NP_775287 NP_775289 NP_001263287 NP_109641 NP_663749 NP_663750 Location (UCSC) Chr 10: 101.83 – 101.84 Mb Chr 19: 45.78 – 45.8 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.^[6]

See also

• Voltage-gated potassium channel