Calsenilin

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.^[4][5][6]

KCNIP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E6W
Identifiers
Aliases	KCNIP3, CSEN, DREAM, KCHIP3, potassium voltage-gated channel interacting protein 3
External IDs	OMIM: 604662; MGI: 1929258; HomoloGene: 8382; GeneCards: KCNIP3; OMA:KCNIP3 - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2|2 F1 Start 127,298,418 bp[1] End 127,364,014 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 left lobe of thyroid gland Amygdala right lobe of thyroid gland nucleus accumbens caudate nucleus Hypothalamus putamen hippocampus proper Top expressed in lumbar spinal ganglion primary visual cortex superior frontal gyrus piriform cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex medial dorsal nucleus subiculum prefrontal cortex medial geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding calcium ion binding sequence-specific DNA binding potassium channel activity transcription corepressor activity voltage-gated ion channel activity metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding potassium channel regulator activity transmembrane transporter binding Cellular component cytoplasm axon terminus cytosol Golgi apparatus membrane voltage-gated potassium channel complex axon dendrite protein-DNA complex endoplasmic reticulum nucleus plasma membrane Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of ion transmembrane transport negative regulation of transcription by RNA polymerase II ion transport transcription, DNA-templated potassium ion transport potassium ion transmembrane transport protein localization to plasma membrane intracellular protein transport regulation of potassium ion transmembrane transport signal transduction apoptotic process negative regulation of nucleic acid-templated transcription cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30818 56461 Ensembl n/a ENSMUSG00000079056 UniProt Q9Y2W7 Q9QXT8 P0C092 RefSeq (mRNA) NM_001034914 NM_013434 NM_001111331 NM_001291005 NM_019789 RefSeq (protein) NP_001030086 NP_038462 NP_001104801 NP_001277934 NP_062763 Location (UCSC) n/a Chr 2: 127.3 – 127.36 Mb PubMed search [2] [3]
Wikidata
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Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.^[7][8] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.^[9] Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

Interactions

Calsenilin has been shown to interact with PSEN1^[4][10] and PSEN2.^[4][11]

See also

• Voltage-gated potassium channel