Neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc.^[1] All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.^[2]

Members of NCS family

• Highly evolutionarily conserved ^[3]
• NCS1 (Frequenin)^[4]
• VILIP-1 (Visinin-like-protein-1)
• HPCAL4 (Visinin-like-protein-2)
• HPCAL1 (Visinin-like-protein-3)
• hippocalcin
• neurocalcin
• recoverin
• Guanylate cyclase activator proteins (GCAPs)
• Potassium Channel interacting proteins (KChIPs 1–4), including:

KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4