KCNK7

Potassium channel, subfamily K, member 7, also known as KCNK7 or K_2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K_2P7.1 is a potassium channel containing two pore-forming P domains.^[5][6][7] Multiple transcript variants encoding different isoforms have been found for this gene.^[8]

KCNK7
Identifiers
Aliases	KCNK7, K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7
External IDs	OMIM: 603940; MGI: 1341841; HomoloGene: 43131; GeneCards: KCNK7; OMA:KCNK7 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,592,836 bp[1] End 65,595,996 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,754,395 bp[2] End 5,757,137 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg skin of arm human penis nipple vulva gingival epithelium skin of thigh skin of hip vagina Top expressed in lip esophagus skin of external ear embryo granulocyte embryo embryo ganglion cell layer hair follicle skin of back More reference expression data BioGPS n/a
Gene ontology Molecular function potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport stabilization of membrane potential potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10089 16530 Ensembl ENSG00000173338 ENSMUSG00000024936 UniProt Q9Y2U2 Q9Z2T1 RefSeq (mRNA) NM_033456 NM_005714 NM_033347 NM_033348 NM_033455 NM_001004138 NM_010609 RefSeq (protein) NP_005705 NP_203133 NP_203134 NP_258416 NP_034739 Location (UCSC) Chr 11: 65.59 – 65.6 Mb Chr 19: 5.75 – 5.76 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.^[8]

See also

• Tandem pore domain potassium channel