KCNMB1

Calcium-activated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNMB1 gene.^[5][6][7]

KCNMB1
Identifiers
Aliases	KCNMB1, BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1, potassium calcium-activated channel subfamily M regulatory beta subunit 1
External IDs	OMIM: 603951; MGI: 1334203; HomoloGene: 3054; GeneCards: KCNMB1; OMA:KCNMB1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.1 Start 170,374,671 bp[1] End 170,389,634 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 33,913,013 bp[2] End 33,923,641 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis popliteal artery tibial arteries right coronary artery muscle layer of sigmoid colon seminal vesicula saphenous vein thoracic aorta ascending aorta Descending thoracic aorta Top expressed in lumbar spinal ganglion ascending aorta aortic valve rib sphenoid bone Meckel's cartilage tunica media of zone of aorta humerus fibula scapula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-activated potassium channel activity potassium channel regulator activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane Biological process detection of calcium ion response to calcium ion potassium ion transport ion transport chemical synaptic transmission ageing cellular response to hypoxia cellular response to bile acid positive regulation of potassium ion transmembrane transport cellular response to ethanol potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3779 16533 Ensembl ENSG00000145936 ENSMUSG00000020155 UniProt Q16558 Q8CAE3 RefSeq (mRNA) NM_004137 NM_031169 RefSeq (protein) NP_004128 NP_112446 Location (UCSC) Chr 5: 170.37 – 170.39 Mb Chr 11: 33.91 – 33.92 Mb PubMed search [3] [4]
Wikidata
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Function

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.^[7] Beta subunits (beta 1-4) are highly tissue specific in their expression, with beta-1 being present predominantly on vascular smooth muscle. Endothelial cells are not known to express beta-1 subunits. Beta-1 is also known to be expressed in urinary bladder and in some regions of the brain. Association of the beta-1 subunit with the BK channel increases the apparent Ca²⁺ sensitivity of the channel and decreases voltage dependence.^[8]

See also

• BK channel
• Voltage-gated potassium channel