KCNMB4

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.^[5][6][7]

KCNMB4
Identifiers
Aliases	KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
External IDs	OMIM: 605223; MGI: 1913272; HomoloGene: 8721; GeneCards: KCNMB4; OMA:KCNMB4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 70,366,290 bp[1] End 70,434,292 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 116,253,766 bp[2] End 116,309,783 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell postcentral gyrus entorhinal cortex hippocampus proper corpus callosum superior frontal gyrus middle temporal gyrus lateral nuclear group of thalamus external globus pallidus prefrontal cortex Top expressed in primary motor cortex lobe of cerebellum cingulate gyrus facial motor nucleus cerebellar vermis globus pallidus medial dorsal nucleus spermatocyte prefrontal cortex habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding calcium-activated potassium channel activity potassium channel regulator activity Cellular component integral component of membrane integral component of plasma membrane plasma membrane voltage-gated potassium channel complex membrane Biological process ion transport action potential neuronal action potential regulation of vasoconstriction chemical synaptic transmission detection of calcium ion potassium ion transport regulation of neurotransmitter secretion potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27345 58802 Ensembl ENSG00000135643 ENSMUSG00000054934 UniProt Q86W47 Q9JIN6 RefSeq (mRNA) NM_014505 NM_021452 RefSeq (protein) NP_055320 NP_067427 Location (UCSC) Chr 12: 70.37 – 70.43 Mb Chr 10: 116.25 – 116.31 Mb PubMed search [3] [4]
Wikidata
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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.^[7]

See also

• BK channel
• Voltage-gated potassium channel