KCNN1

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the K_Ca2.1 protein.^[4]

KCNN1
Identifiers
Aliases	KCNN1, KCa2.1, SK1, SKCA1, hSK1, potassium calcium-activated channel subfamily N member 1
External IDs	OMIM: 602982; MGI: 1933993; HomoloGene: 37595; GeneCards: KCNN1; OMA:KCNN1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,951,293 bp[1] End 18,000,080 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe cingulate gyrus anterior cingulate cortex prefrontal cortex Amygdala Region I of hippocampus proper dorsolateral prefrontal cortex Brodmann area 9 ganglionic eminence putamen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function small conductance calcium-activated potassium channel activity calcium-activated potassium channel activity calmodulin binding protein heterodimerization activity Cellular component integral component of membrane voltage-gated potassium channel complex soma plasma membrane membrane neuron projection Biological process potassium ion transport ion transport potassium ion transmembrane transport chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3780 84036 Ensembl ENSG00000105642 ENSMUSG00000002908 UniProt Q92952 Q9EQR3 RefSeq (mRNA) NM_002248 NM_032397 RefSeq (protein) NP_002239 NP_115773 NP_001350336 NP_001350337 Location (UCSC) Chr 19: 17.95 – 18 Mb n/a PubMed search [2] [3]
Wikidata
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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The K_Ca2.1 protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. The KCNN1 gene is a member of the KCNN family of potassium channel genes.^[4]

See also

• SK channel
• Voltage-gated potassium channel