KCNN4

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the K_Ca3.1 protein.^[5]

KCNN4
Identifiers
Aliases	KCNN4, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, IK, DHS2, potassium calcium-activated channel subfamily N member 4
External IDs	OMIM: 602754; MGI: 1277957; HomoloGene: 1696; GeneCards: KCNN4; OMA:KCNN4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.31 Start 43,766,533 bp[1] End 43,780,976 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 24,069,688 bp[2] End 24,086,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa parotid gland minor salivary glands mucosa of transverse colon granulocyte skin of leg trachea skin of abdomen placenta lymph node Top expressed in parotid gland Paneth cell lacrimal gland submandibular gland fetal liver hematopoietic progenitor cell crypt of lieberkuhn of small intestine lumbar spinal ganglion thymus transitional epithelium of urinary bladder lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein phosphatase binding calcium-activated potassium channel activity potassium channel activity calmodulin binding small conductance calcium-activated potassium channel activity Intermediate conductance calcium-activated potassium channel activity Cellular component integral component of membrane membrane voltage-gated potassium channel complex plasma membrane vesicle soma neuron projection Biological process calcium ion transport positive regulation of protein secretion cell volume homeostasis potassium ion transport saliva secretion ion transport positive regulation of T cell receptor signaling pathway immune system process defense response phospholipid translocation stabilization of membrane potential potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3783 16534 Ensembl ENSG00000104783 ENSMUSG00000054342 UniProt O15554 O89109 RefSeq (mRNA) NM_002250 NM_001163510 NM_008433 RefSeq (protein) NP_002241 NP_001156982 NP_032459 Location (UCSC) Chr 19: 43.77 – 43.78 Mb Chr 7: 24.07 – 24.09 Mb PubMed search [3] [4]
Wikidata
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Function

The K_Ca3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.^[5]

History

The channel activity was first described in 1958 by György Gárdos in human erythrocytes.^[6] The channel is also named Gardos channel because of its discoverer.

See also

• SK channel
• Voltage-gated potassium channel
• Senicapoc