KCNQ5

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.^[5][6][7][8]

KCNQ5
Identifiers
Aliases	KCNQ5, Kv7.5, potassium voltage-gated channel subfamily Q member 5, MRD46
External IDs	OMIM: 607357; MGI: 1924937; HomoloGene: 28270; GeneCards: KCNQ5; OMA:KCNQ5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q13 Start 72,621,792 bp[1] End 73,198,853 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A4 Start 21,468,627 bp[2] End 22,032,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pons Brodmann area 23 tibialis anterior muscle Skeletal muscle tissue of rectus abdominis deltoid muscle quadriceps femoris muscle Brodmann area 46 vastus lateralis muscle superior frontal gyrus Top expressed in primary motor cortex olfactory tubercle nucleus accumbens piriform cortex sternocleidomastoid muscle prefrontal cortex temporal muscle globus pallidus digastric muscle temporal lobe More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity potassium channel activity protein binding voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity calmodulin binding Cellular component membrane clathrin coat integral component of membrane integral component of plasma membrane voltage-gated potassium channel complex plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56479 226922 Ensembl ENSG00000185760 ENSMUSG00000028033 UniProt Q9NR82 Q9JK45 RefSeq (mRNA) NM_001160130 NM_001160132 NM_001160133 NM_001160134 NM_019842 NM_001160139 NM_023872 NM_001310477 RefSeq (protein) NP_001153602 NP_001153604 NP_001153605 NP_001153606 NP_062816 NP_001153611 NP_001297406 NP_076361 Location (UCSC) Chr 6: 72.62 – 73.2 Mb Chr 1: 21.47 – 22.03 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.^[8]

Interactions

KCNQ5 has been shown to interact with KvLQT3.^[9]

See also

• Voltage-gated potassium channel