KCNU1

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the K_Ca5.1 protein.^[4]

KCNU1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HPF
Identifiers
Aliases	KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3, potassium calcium-activated channel subfamily U member 1
External IDs	OMIM: 615215; MGI: 1202300; HomoloGene: 7392; GeneCards: KCNU1; OMA:KCNU1 - orthologs
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8|8 A2 Start 26,339,651 bp[1] End 26,427,967 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm bone marrow cell caput epididymis substantia nigra monocyte mammary gland female breast subcutaneous adipose tissue male reproductive gland prostate Top expressed in spermatid morula lumbar spinal ganglion seminiferous tubule spermatocyte facial motor nucleus blastocyst islet of Langerhans embryo anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity large conductance calcium-activated potassium channel activity ion channel activity potassium channel activity voltage-gated ion channel activity calcium-activated potassium channel activity outward rectifier potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport transmembrane transport potassium ion transmembrane transport sperm-egg recognition reproductive process regulation of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 157855 16532 Ensembl n/a ENSMUSG00000031576 UniProt A8MYU2 O54982 RefSeq (mRNA) NM_001031836 NM_008432 RefSeq (protein) NP_001027006 NP_032458 Location (UCSC) n/a Chr 8: 26.34 – 26.43 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.^[5][6][7]